LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights
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چکیده
منابع مشابه
LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights
Pathway or gene set over-representation analysis (ORA) has become a routine task in functional genomics studies. However, currently widely used ORA tools employ statistical methods such as Fisher's exact test that reduce a pathway into a list of genes, ignoring the constitutive functional non-equivalent roles of genes and the complex gene-gene interactions. Here, we develop a novel method named...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep18871